Empathy and Reversed Empathy of Stress in Mice

Empathy is an emotional response to display of distress in others and reversed-empathy is an emotional response to non-distressed others in distressed subjects. Stress has memory enhancing effect on aversive experience. Here, I examine empathy and reversed empathy using the memory enhancing effects of stress in mice. Restrain stress enhanced aversive memory of a floor with electric shock, but restrain stress, with cage mates also restrained, reduced the enhancing effect. On the other hand, restrain stress with free-moving cage mates increased the memory enhancing effect, suggesting the stronger stress. This is the reversed-empathy. Level of corticosterone is the highest after the restrain with free-moving mates and lowest after the restrain with restrained mates.